Molecular Books

High Throughput Screening: Methods and Protocols (Methods in Molecular Biology) (Methods in Molecular Biology)

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Subjects -> Medicine -> Basic Science -> Microbiology
Subjects -> Medicine -> Basic Science -> General
Subjects -> Medicine -> Basic Science -> General AAS

Editorial Review:

In High Throughput Screening, leading scientists and researchers expert in molecular discovery explain the diverse technologies and key techniques used in HTS and demonstrate how they can be applied generically. Writing to create precisely the introductory guidebook they wish had been available when they started in HTS, these expert seasoned authors illuminate the HTS process with richly detailed tutorials on the biological techniques involved, the management of compound libraries, and the automation and engineering approaches needed. Extensive discussions provide readers with all those key elements of pharmacology, molecular biology, enzymology, and biochemistry that will ensure the identification of suitable targets and screens, and detail the technology necessary to mine millions of data points for meaningful knowledge.

Validation of Cell-Based Assays in the GLP Setting: A Practical Guide

Amazon Price: $114.00 List Price: $150.00 Usually ships in 24 hours By: Wiley Amazon Marketplace: 32 new & used starting at $105.00

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Subjects -> Medicine -> Pharmacology -> General

Editorial Review:

The use of cell-based assays within pharmaceutical and biotechnology companies is driven in large part by the need to evaluate the plethora of drug targets derived from genomics and proteomics. In addition, the potential of biomarkers to facilitate the development of effective and safe drugs is being recognized as an integral part of all phases of drug development, and cell-based technologies are a critical part of biomarker discovery and development. Despite this critical role, cell-based assays have not been standardized and made compliant with Good Laboratory Practice guidelines.  

In this book, the editors have collected assays for which validation procedures have been developed, making this a vital purchase for anyone using such assays in drug development.

This book: 

• Describes the development, optimization and validation of cell-based assays, including procedural documentation required for Good Laboratory Practice
• Presents validations of cell-based assays for select targets, with step-by-step instructions, allowing the reader to reproduce the assay conditions and results
• Provides details of techniques used in the evaluation of immunodeficiency, autoimmune and oncological disorders, including assessment of cancer vaccines
• Offers a compendium of validation parameters that need to be considered when using these methods to develop a new drug
• Includes detailed protocols for the evaluation of cytokines and of neutralizing antibodies directed against protein therapeutics

Validation of Cell-based Assays in the GLP Setting provides the professional with an invaluable reference source, featuring key guidelines. The book will prove extremely useful to all scientists working in the areas of drug development. 

Organic Chemistry of Drug Design and Drug Action (1)

Richard B. Silverman

List Price: $77.95 By: Academic Press Amazon Marketplace: 25 new & used starting at $14.91

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Subjects -> Medicine -> Basic Science -> Biochemistry
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Customer Reviews:
Total reviews: 5 Average rating: 4.5 of 5

Compulsory book for every biochemistry student 5 out of 5 stars.
8 of 9 people found this review helpful.

This book is very good introduction in the major aspects of the chemistry of the drugs. It explains with good schemes the reactions of drugs and others important mechanisms. The book is scientifically well written and enjouyable to read. The graphic images of molecules integrate well with the written aspects of book. Book covers major areas of pharmaceutical drug research, integrates the chemical and pharmacological aspects of drugs, and discusses the essentials of drug activity and mechanisms.

Editorial Review:

This is a new approach to the teaching of medicinal chemistry. The knowledge of the physical organic chemical basis of drug design and drug action allows the reader to extrapolate to the many related classes of drugs described in standard medicinal chemistry texts. Students gain a solid foundation to base future research endeavors upon: drugs not yet developed are thus covered!

* Emphasizes the use of the principles of physical organic chemistry as a basis for drug design
* Discusses organic reaction mechanisms of clinically important drugs with mechanistic schemes
* Uses figures and literature references extensively throughout
* This text is not merely a "compilation of drugs and uses," but features selected drugs as examples of the organic chemical basis for any and all drug design applications

Molecular Analysis and Genome Discovery

Amazon Price: $100.00 List Price: $100.00 Usually ships in 24 hours By: Wiley Amazon Marketplace: 21 new & used starting at $42.30

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Subjects -> Medicine -> Internal Medicine -> Infectious Disease -> Communicable Diseases
Subjects -> Medicine -> Pharmacology -> General
Subjects -> Medicine -> Pharmacology -> General AAS

Editorial Review:

This advanced level textbook provides a comprehensive overview of recent developments in the area of molecular based diagnostics (including nucleic acids, biosensors and immunoessays) of disease markers. It also covers the impact of techniques such as in vitro nucleic acid amplifications (e.g. PCR) and other amplification methods, as well as gene and biochip production and automated techniques such as fluorescent sequencing.

The book discusses key concepts where new and merging areas, including pharmacogenomics, proteomics and functional genomics, are being researched and developed. In addition, examples are given where this new area of bioscience has or may be successfully applied.

Apoptosis Methods in Pharmacology and Toxicology: Approaches to Measurement and Quantification (Methods in Pharmacology and Toxicology)

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Subjects -> Medicine -> Internal Medicine -> Neurology -> General AAS
Subjects -> Medicine -> Pharmacology -> Toxicology
Subjects -> Medicine -> Pharmacology -> General

Editorial Review:

Dr. Myrtle A. Davis has assembled a panel of cutting-edge scientists to describe their best methods for detecting, illuminating, and quantifying apoptotic mechanisms in a way that is useful for the design of toxicology and pharmacology studies. These state-of-the-art techniques include flow cytometric, fluorometric, and laser scanning methods for quantifying and characterizing apoptosis, as well as protocols for the use of DNA microarray technology, high throughput screens, and ELISA. Immunocytochemical methods for measuring biochemical and molecular endpoints in tissue sections will be highly useful for those carrying out studies in whole animal models as opposed to cell culture systems.

Molecular Targeting in Oncology (Cancer Drug Discovery and Development) (Cancer Drug Discovery and Development)

Amazon Price: $179.00 List Price: $179.00 Usually ships in 24 hours By: Humana Press Amazon Marketplace: 36 new & used starting at $79.74

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Subjects -> Medicine -> Basic Science -> Immunology
Subjects -> Medicine -> Internal Medicine -> Oncology -> General
Subjects -> Medicine -> Internal Medicine -> Oncology -> General AAS

Editorial Review:

In Molecular Targeting in Oncology, authors present an overview of the development of targeted therapies for the treatment of cancer with an emphasis on clinical application. The volume covers the complexity of the rapidly developing area of targeted therapies for the treatment of patients with cancer and is structured in a way so readers may begin with chapters that most interest them and work through the rest of the chapters in the order of their choice.

The volume is divided into five sections that cover the most important elements of drug development. The first section focuses on approaches using targeted therapies to inhibit cell growth. The second section describes how clinicians are evaluating targeted therapies in specific organ systems. The third section illustrates how various classes of pharmacologic and immunologic agents are developed for individual molecular targets. The fourth section details new drugs that have novel mechanisms of action. The final section looks to the future of targeted therapeutics and includes chapters on appropriate patient selection, use of combination therapy, dealing with tumor cell resistance, and more. Comprehensive and cutting-edge, Molecular Targeting in Oncology is an essential reference for those working in the field.

Novel Anticancer Drug Protocols (Methods in Molecular Medicine) (Methods in Molecular Medicine)

Amazon Price: $145.00 List Price: $145.00 Usually ships in 24 hours By: Humana Press Amazon Marketplace: 29 new & used starting at $83.16

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Subjects -> Medicine -> Internal Medicine -> Oncology -> General

Editorial Review:

This book not only surveys the whole arena of novel anticancer drug targets, but also presents a wide-ranging selection of cutting-edge techniques currently being applied throughout novel antitumor drug discovery and development. The methods are applied to experiments involving such topics as immunotherapy, angiogenesis, cancer metastasis, the cell cycle, signal transduction inhibitors, apoptosis, antibodies, antisense molecules, microarray gene expression, flow cytometry, and PET imaging for cancer target validation. There are also proven methods for the preclinical identification of drug targets and for target validation during the clinical trials of novel agents.

Molecular Cancer Therapeutics: Strategies for Drug Discovery and Development

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Subjects -> Medicine -> Internal Medicine -> Oncology -> General AAS
Subjects -> Medicine -> Internal Medicine -> General AAS

Editorial Review:

Molecular Cancer Therapeutics covers state-of-the-art strategies to identify and develop cancer drug target molecules and lead inhibitors for clinical testing. It provides a thorough treatment of drug target discovery, validation, and development. The introductory chapters provide an overview of pathways to discovery and development of molecular cancer therapeutics. Subsequent chapters progress from initial stages of drug target discovery to drug discovery, development, and testing in preclinical and clinical models. Topics include drug lead screening, drug-to-lead development, proof-of-concept studies, medicinal chemistry issues, intellectual property concerns, and clinical development.
This invaluable reference promotes understanding of steps involved in developing drug leads for industrial partnering and development. It provides an overview of the strategies for discovery and validation of drug target molecules, and discusses cell- and molecule-based drug screening strategies, as well as mouse models for cancer. Coverage also includes how to refine drug leads for suitability in clinical testing, the special issues of clinical testing of molecular-targeted drugs, and intellectual property concerns.

EGFR Signaling Networks in Cancer Therapy (Cancer Drug Discovery and Development) (Cancer Drug Discovery and Development)

Amazon Price: $149.00 List Price: $149.00 Usually ships in 24 hours By: Humana Press Amazon Marketplace: 19 new & used starting at $133.96

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Subjects -> Medicine -> Internal Medicine -> Oncology -> General AAS
Subjects -> Medicine -> Pharmacology -> General

Editorial Review:

The epidermal growth factor (EGF) receptor and its downstream signal transduction networks have been implicated in the ontology and maintenance of tumor tissues, which has motivated the discovery and development of molecularly targeted anti-EGFR therapies. Edited by John Haley and William J. Gullick, EGFR Signaling Networks in Cancer Therapy, is separated into two sections. The first of which probes the molecular pathways and the intersection of signaling networks which are frequently deregulated in human cancers, with a view to describing EGF receptor in a tumor tissue specific context. Meanwhile, the second section illustrates the many ways in which EGF receptor contribute to abnormal survival and migration signaling in cancer cells and to epithelial to mesenchymal transition and metastasis. The book also describes the mitogenic, survival, adhesive and migratory pathways within a framework of interacting subsystems that contribute to the activity and physiological regulation of the receptor in normal and neoplastic tissues. Even though there is still much to learn, this volume explores this fascinating system with compelling information.