Malcolm Rowland, Thomas N Tozer
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By: Lippincott Williams & Wilkins
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Customer Reviews:
Total reviews: 4
Average rating: 4.5 of 5
Great book, the gold standard intro 5 out of 5 stars.
18 of 18 people found this review helpful.
This book is a very finely crafted comprehensive introduction to pharmacokinetics, with enough pharmacodynamics to give one context. If you are new to PK/PD and need to understand and work with the subject matter this is an EXCELLENT starting point and a fine reference. The prose is clear, the organization thoughtful, and the figures and diagrams are masterful - best in class. The authors are both renowned academics with extensive industrial experience. That background shines through in the thoughtful way that topics are motivated and explained. I found the questions useful and thought-provoking. Isn't it the case that the more iron one pumps in the gym, the stronger one is on the playing field?One thing that I would add to this book (and most other PK books I've seen) would be a comprehensive listing of the different math models (one or two compartment, IV, or zero or first order input, etc), highlighting different uses (closed form solutions are easiest to use for parameter estimations, ODE formulations for repeat dosing, etc.) and their different parameterizations. This book contains some of this information (e.g. Table 19-1), but an appendix with this info would be useful. An additional improvement with great teaching utility might be an elementary modeling/estimation program for MS-Excel.
For those needing an overview of PK (e.g. a pharma executive responsible for a development program) without a lot of the details necessary for practitioners, a less-comprehensive book that is also very good is Peter Welling's "Pharmacokinetics". Gabriellson's and Weiner's book "PK and PD Data Analysis" has a more spotty overview of the basic subject matter, but does have descriptions of many techniques not found elsewhere. The latter book is "WinNonLin-centric" (WinNonLin is a program written by one of the authors) which may be what is wanted.
My favorite intro book and basic referencer for PK is definitely Rowland and Tozer. Bravo!
Editorial Review:
Since pharmacokinetics can greatly affect how different patients respond to the same drug, both students and physicians need a basic clinical understanding of this vital area. The Third Edition of Clinical Pharmacokinetics provides a practical perspective, with these added features considerations of both stereochemistry and the increasing number of polypeptide and protein drugs being developed; the range and number of problems at the end of each chapter has been expanded; a second color added to make the text more user friendly; important equations highlighted by shading.